Does Phentermine cause heart disease?

By: Scottsdale Weight Loss Center

Published: May 10, 2019

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It has been well documented that lifestyle modifications can assist many in their weight loss journey. Lifestyle interventions include dietary modifications and exercise as a root change. Why are we hesitant to using pharmacotherapies to treat obesity, especially long term? Using Phentermine long term has remained a debated topic despite newer antiobesity medications having the long-term use label. There have been several papers (Hendricks et al) previously reviewed on the efficacy of long term phentermine use specifically, yet a majority has not accepted this. This study further validates the importance of this option. Obesity is a serious and chronic disease and we must treat it as such.

In this study there were three main outcomes evaluated at 6, 12 and then 24 months:

Heart Rate
Blood Pressure
Cardiovascular event or death

Observation of heart rate (HR) showed a slight increase which is to be expected if we understand the drug’s mechanism of action. The magnitude of increase was not significant and cessation of phentermine showed immediate return to baseline. (<.6bpm)

Systolic Blood Pressure (SBP) decreased with weight loss and long term phentermine use. Even in those with hypertension, there was a net-lowering effect in SBP with weight loss and long term phentermine use.

The results showed consistently that there was significantly greater weight loss with phentermine use, even up to 2 years. It is important to note that 30% of the cohort were on phentermine at least one duration >12 months. No observed increase in risk for incident cardiovascular event or death over 3 years of follow up.

Discontinuation of phentermine resulted in weight regain.

Safety and Effectiveness of Longer-Term Phentermine Use: Clinical Outcomes from an Electronic Health

Record Cohort

https://doi.org/10.1002/oby.22430

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Nick's Story

"I wish I would have come here first. We spend all our time reacting to the next great weight loss tip or program. It might work for a while, but does not last and we end up yo-yoing from one fad to the next – as we gain more weight." Read More

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Lost 44.5 lbs

"I had no trouble adhering to the meals and they really helped catapult my progress! The classes were so beneficial to me because they helped change my thinking about how I viewed health, nutrition, and fitness.

I will always have my relationship with Scottsdale Weight Loss Center. They truly helped me change my life forever." Read More

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Lost 60 lbs

"Dr. Ziltzer and everyone who I have come in contact with at the Scottsdale Weight Loss office have been so encouraging and I look forward to seeing them each week. It is now a year and 2 months later since I started. I am down 60 lbs., which is the average amount a 9-year-old weighs, it is crazy to think I lost a whole person! I feel amazing, I hit my goal weight in November 2021 just before Thanksgiving. Nothing on my body hurts anymore..." Read More

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Lost 66 lbs

"The best thing I did was call the Scottsdale Weight Loss Center. I have a lot more energy, I'm not hungry, and it feels great.

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Lost 101 lbs

"Here I am at the lowest I have been since high school weighing in at 155lbs. I have lost 101 lbs, BMI of 39 when I started, to 21.6, and of course at body fat % of 47.1 to 26.5%. I told myself by my 30th birthday I wanted to be confident in the way I look and I owe it all to SWLC. The entire staff is so welcoming and they are rooting for you just as much as you are rooting for yourself...." Read More

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      Excellent rating  
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     Trustindex verifies that the original source of the review is Google. Everything perfect
     
   Andi K 
 5 days ago
 
 
 
 
   Trustindex verifies that the original source of the review is Google. I landed at Scottsdale Weight Loss 13 years ago and lost 50 pounds….regained 10 and then lost them again, plus another 20.  It is a great program, and all the professionals are amazing and caring.
     
   Mj W 
 11 days ago
 
 
 
 
   Trustindex verifies that the original source of the review is Google. SWL has been a God send to me! Dr. Guzman & staff especially Lilia & Bianca! They’re so supportive & professional I have lost approx 50 pounds over the year at my own pace.
     
   Donna L 
 13 days ago
 
 
 
 
   Trustindex verifies that the original source of the review is Google. Great place 30 lbs.and counting thank you And now it is over 40 lbs. and counting thank you great job
     
   John J 
 29 days ago
 
 
 
 
   Trustindex verifies that the original source of the review is Google. I cannot say enough wonderful things about Dr Robert Ziltzer! He helped me reach my ideal weight and more importantly maintain it for over 2 years. He has also helped me keep my blood pressure exactly where my internist wanted it. Dr Ziltzer is not only exceptional in weight management but also a truly gifted internet’s. His knowledge, kindness, and dedication are remarkable. I am deeply grateful for his care and recommend him whole heartedly!
     
   Merle S 
 36 days ago
 
 
 
 
   Trustindex verifies that the original source of the review is Google. The staff at the Phoenix office are great! My experience with Dr deGuzman has been wonderful. Miriam has always been very helpful and makes the office visits pleasant and personal. The medical assistants have always been professional and great to help meet my goals.
     
   Paula S 
 39 days ago
 
 
 
 
   Trustindex verifies that the original source of the review is Google. I really felt comfortable with Kristen at my initial appointment.  Everyone at the center was caring and friendly, from Bianca, at the front desk, to Lily, who is the MA.  Kristen listened to my frustrations and prior disappointments about what has not worked, and is confident that she can help me achieve my goals of weight loss.  I am looking forward and excited to see the success I will attain.
     
   Joyce K 
 46 days ago
 
 
 
 
   Trustindex verifies that the original source of the review is Google. My weight loss is going well because of Scottsdale Weight Loss Center.  I couldn’t do it without them
     
   Robert D 
 48 days ago
 
 
 
 
   Trustindex verifies that the original source of the review is Google. Amazing staff and great program!  Feeling great!
     
   Brian H 
 50 days ago
 
 
 
 
   Trustindex verifies that the original source of the review is Google. I'd lost 20 pounds on my own and struggled to keep it off.  I decided GLP-1 meds were the next step in losing more and keeping it off.  I wanted a medical doctor supervised program and chose SWLC. I am so very glad I did!  The team in Glendale is so supportive and kind; and when I feel discouraged, they pick me up with positive energy and input.  They really do a great job with encouragement all the time. 6 weeks in I've lost 17 pounds, and am approaching weight loss with a very new perspective.  Also knowing that when I reach my target goal, they'll be there through maintenance and beyond is encouraging as well.  Good to not feel alone on this journey.
     
   Stephanie P 
 64 days ago
 
 
 
 
   Trustindex verifies that the original source of the review is Google. They have encouraged and been there through every tough situation. Definitely the team to lean on.
     
   Theresa G 
 69 days ago
 
 
 
 
   Trustindex verifies that the original source of the review is Google. Everyone is pretty amazing but Kim the NP is absolutely one of the best practitioners I’ve ever met !
     
   Mary K 
 70 days ago
 
 
 
 
 
 
  
 
 
 
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