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It has been previously shown that 5% weight loss leads to a 50% reduction hypertension and diabetes risk, or 15 pounds for a 200 lb. individual. Long term weight loss is difficult as it leads to compensatory reduction of Leptin, which reduces metabolism and increases appetite at the level of the hypothalamus. Also, weight loss causes an increase in baseline and peak levels of the appetite stimulating hormone ghrelin. These changes persist for at least one year, and likely lifelong. [Read more]